“There is no formal partnership agreement between UCL and SonaCare. Please note, UCL is a separate entity from UCLH so we cannot provide a formal response on behalf of UCLH. I understand they have responded separately on this and explained the nature of the relationship with UCLH.”
“SonaCare Medical, a global leader in minimally invasive high intensity focussed ultrasound (HIFU) technologies, announced early May that it has partnered with University College London (UCL) to create a HIFU Center of Excellence. The Center will provide physician training and proctoring along with clinical studies, patient satisfaction research and advanced technology development associated with two innovative HIFU systems: the Sonatherm laparoscopic HIFU surgical ablation system and the Sonablate 500 transrectal HIFU surgical ablation system. According to Mark Emberton, MD, Director of the Division of Surgery and Interventional Science, University College London, "our collaboration with SonaCare Medical's innovative technology provides a great platform for us to help expand the use of HIFU in a responsible and effective way. Tissue preserving strategies have been used successfully in other solid organ cancers, such as kidney cancer with great results. Published data from our practice continue to demonstrate that focal therapy delivers good cancer control along with a significant reduction in treatment side effects, which suggests a new option in a spectrum of prostate cancer care that, based on risk profile, could effectively balance clinical benefits and quality of life". "The highly precise Sonablate 500 HIFU transrectal system has already proven an effective way to transition from treating the entire prostate to treating only the known prostate cancer" added Dr Emberton.”
“A study published in European Urology (Marconi et al; 76 (2019) 27-30) in March of that year by UCLH with Guys, Kings and Imperial found: “Specifically, we identified that men experiencing an infield recurrence had almost four times the risk of developing biochemical failure after S-RALP, independent of margin status, Gleason grade group, PA, or pT stage. This suggests that those experiencing infield recurrence might have a more aggressive cancer phenotype and are thus more likely to need multimodal therapy with or without systemic therapy. One hypothesis for this finding is that an initial incomplete ablation might result in the development of “ablation resistant” clones that repopulate the ablation field and metastasise locoregionally. The biological mechanism of this phenomenon is yet to be described and further research exploring the role of genetic and epigenic alterations in these tumours is ongoing.”
“A study published in BMC Urology (Thompson et al: BMC Urology (2020) 20.81) on 1st July of that year by UCLH found “Nerve sparing was not feasible due to HIFU-induced NVB fibrosis in 60.8%, suspicion of posterolateral EPE on MRI or high-grade cancer near the NVB in 23.0% and erectile dysfunction in 17.9%”
“Medicine is an applied science and clinical trials are a crucial aspect of medical research. There is therefore a significant degree of cross-fertilisation between academic research and the treatment of patients in clinical settings. That does not mean, however, that there is no meaningful distinction between academic and clinical roles and institutions; the two remain separate and distinct.”