“Q. ... the similarities between the MathCAD programs and the Java classes which you have identified in your report are simply this, that both sets of programs carry out the same task, or at least have programs in them to carry out the same task, by reference to the same algorithms and equations? A. Yes, that has to be true. Q. So it is the function of the software which is common to both? A. Well, they contain the same algorithms. Q. Yes? A. So, yes. Q. They are there to perform equations and the same equations are there in both? A. Yes.”
“In the same way as the aircraft industry carries out extensive simulations of how a new plane would perform, the Virtual Human would be an immensely valuable tool for improving the design of safe and effective drugs at lower cost than is currently the case.”
“Whereas the aircraft industry has used computer simulation to evaluate the performance of its products (aircraft) before they are built (and fly) for many years, the pharmaceutical industry has been slow to apply a similar principle to the evaluation of its products (drugs) before they are tested in humans for the first time. Simcyp is one of the first systematic attempts to do this: and does it uniquely with respect to incorporating information on in vitro human drug metabolism.”
“JR spoke with David Leahy. Due to difficulty of employing a suitable candidate they would still prefer to be the employer. They have no problem with IP going to Uni. Simply see the project as conversion of IP software to a more marketable format. See the involvement of other parties as feedback from customers to develop the programme for their needs. Support they will provide is in kind support. They want first option for an exclusive license to market - with a royalty return.”
“I recall that David Leahy made it clear that he was representing Cyprotex and not Medeval and that Cyprotex was a separate operating division from Medeval. David Leahy suggested that Cyprotex were about to split away from Medeval and was looking for outright investors to assist in this process. ... Therefore I made no reference to Medeval in any of the draft Research Agreements that I sent to David Leahy and I was not corrected on this point with any of the subsequently amended agreements which I later sent to Cyprotex.”
“RESEARCH AGREEMENT between the University of Sheffield, and ‘The Sponsors’ ... . WHEREAS, the research programme contemplated by this agreement is of mutual interest and benefit to the University and to the Sponsors NOW THEREFORE, the parties agree as follows: 1. SPONSORS. As listed in Appendix 2. 2. STATEMENT OF WORK. The University shall perform the “Programme of Research” entitled “SIMCYP - a Windows Based Simulation Program to Assess the Likelihood of Metabolic Drug-Drug Interactions from In-Vitro Data as described in Appendix 1. The University agrees to liaison meetings with the Sponsors as mutually acceptable to provide project progress information. 3. PRINCIPAL INVESTIGATORS. The research will be conducted by Dr Amin Rostami, Professor Geoff Tucker and Dr Martin Lennard. 4. PERIOD OF PERFORMANCE. Notwithstanding the date of this agreement, the “Programme of Research” shall be conducted during the continuous period of 12 months starting not later than1 March 2000 unless otherwise agreed and will be subject to renewal only by mutual agreement of the parties. 5. PAYMENT AND PRICE. The Sponsors will pay the University the sums as set out against the relevant Sponsor’s name in Appendices 3, 4, 5, 6 and 7. 6. TERMINATION. Each Sponsor may withdraw from this agreement upon sixty days written notice given to the University and the other Sponsors. This agreement may only be terminated by the University upon reasonable notice and as soon as practicable as soon as it has been determined that circumstances beyond its control make continuation of the Programme of Research impossible on the basis contemplated by this agreement. In the event that all Sponsors withdraw from this agreement and it is terminated, the University will be reimbursed for all reasonable costs contemplated by this agreement ... and each Sponsor shall only be responsible for a proportion of such approved costs commensurate with the proportion of that Sponsors’s payment of the total project cost as set out in the financial appendices and in any event, no Sponsor shall be liable for such incurred costs in excess of that Sponsor’s agreed payment as set out in the financial appendices nor shall the University be entitled to any payment in excess of the total payment in excess of the total project price specified in Article 5 and the financial appendices. … 7. LIABILITY. (a) The University will exercise reasonable skill and care to ensure the accuracy of the advice, information and drawings provided in connection with the Programme of Research but the University will not accept any liability whatsoever in respect of any claim or claims arising from the use by the Sponsors or by any third party of any such advice, information or drawings. (b) The University shall use its best endeavours to ensure that it will not infringe any third party rights in performance of the Programme of Research and the rights granted to the Sponsors herein. ... the University does not accept any responsibility whatsoever for infringement of such rights. 8. SCIENTIFIC PUBLICATION The Sponsors recognise that the University will wish to publish certain papers, articles, books, pamphlets or published material which makes reference to or contains material arising from the Research Programme and it is the Sponsors intent not to hinder the normal exchange of scientific information which occurs in journals or at scientific meetings. The University agrees that the written permission of each Sponsor will be obtained before such publication or disclosure and the Sponsors will respond to such written requests within 60 (sixty) days of receipt thereof. Such permission will not be withheld longer than is necessary to enable arising intellectual property to be protected and in any event not longer than six months from the date of the University’s request for permission to disclose. Title to and the right to determine the disposition of any copyrights or copyrighted written material first produced or composed in the performance of this research shall remain with the University, provided that the University hereby grants to the Sponsors an irrevocable, royalty-free, paid up, non-exclusive right and licence to reproduce, translate and use all copyright material for its own purposes. The Sponsor has the right to assign such aforesaid rights and licence to its affiliates. 9. INTELLECTUAL PROPERTY RIGHTS (a) All intellectual property in any form owed or existing at the date of this agreement and used in connection with the Programme of Research (“Background IPR”) shall remain the property of the party introducing the same. (b) “Resulting Intellectual Property” shall mean individually and collectively all inventions, improvements and/or discoveries whether or not patentable or capable of other intellectual property protection which are conceived and/or made by one or more members of other agents of the University acting either on their own or jointly with one or more employees of the Sponsors in performance of the Programme of Research and relating to its objectives. (c) All rights to Resulting Intellectual Property under the Programme of Research shall belong in the first instance to the University. (d) Rights to inventions, improvements and/or discoveries, whether or not patentable or capable of other intellectual property protection, relating to the Programme of Research made solely by employees of the Sponsors shall belong to each Sponsor respectively (“Sponsor IPR”). (e) The University hereby grants to each Sponsor a non-exclusive, world-wide, irrevocable, royalty-free licence to use the Resulting Intellectual Property for the purposes of the Sponsors internal research and development in support of the Sponsors own business activities including, but not limited to, dealings with any regulatory authority. The Sponsor has the right to assign or sub-licence such aforesaid rights and licence to its affiliates. To the extent any Sponsor IPR is also requested by a Sponsor to obtain the full benefit of this licence, each Sponsor hereby grants a similar licence to the others as specified in this clause 9(e) (f) The University shall have the right to grant licences to third parties under the Resulting Intellectual Property provided by the University ensure that the rights of each Sponsor under this Agreement are fully protected and in any event, any such licence shall not affect the licence granted to Sponsors set out in clause (e) above. (g) In addition to the licence to be granted to the Sponsors in clause 9(e), the University shall grant to each Sponsor, to the extent that it is free to do so, a nonexclusive licence to use all the University’s Background IPR where such Background IPR is either (i) incorporated into the Programme of Research or (ii) needs to be licensed to Sponsors in order to enable Sponsors to practice lawfully any patent, invention, design or improvement arising from the Programme of Research. Any licence granted to the Sponsors under this sub-clause 9(g) shall be world-wide, irrevocable and royalty free for the purposes of the project and for the purposes of the licence granted under clause 9(e) and thereafter royalty bearing on reasonable terms and conditions to be agreed if the Sponsors wish to use the Resulting Intellectual Property for its own commercial purposes involving the sale or licensing of the software to be developed in the Programme of Research. 10. USE OF NAMES AND CONFIDENTIALITY 10.1 Neither party will use the name of the other in any form of publicity without the written permission of the other. 10.2 The receiving party undertakes to treat as strictly confidential and not to divulge to any other third party, in whole or in part, any information, technical knowledge, know-how, experience, data and business background of a secret and confidential nature relating to the Programme of Research (“Information”) disclosed under this agreement and not to make use of any such Information without the disclosing party’s prior written consent. The receiving party also agrees not to reverse engineer or otherwise analyse any of the materials provided under this agreement. The receiving party further agrees not to reproduce any Information disclosed to it by the other party except for the purposes set forth in this Agreement above and shall limit disclosure of Information to those persons employed or otherwise under the contract with the receiving party who have a legitimate need to know such Information for the purpose set forth herein. Such obligations of confidentiality shall not apply in respect of information that i) was already or comes to be in the public domain or ii) is already know to the recipient or iii) is acquired by the recipient from third party sources or iv) is acquired by the recipient from its own independent research or v) is approved in writing for disclosure by the disclosing party or vi) is required to be disclosed pursuant to any legal or regulatory requirements. … 13. GENERAL (a) This agreement and the documents referred to in it form the entire agreement between the parties relating to the subject matter and supersedes all previous agreements (if any) relating to its subject matter. (b) A waiver by any party of any term or condition of this agreement in one instance shall not be deemed or construed to be a waiver of such term or condition for any similar instance or of any subsequent breach. All rights, remedies, undertakings and obligations herein are cumulative. (c) This agreement may only be amended by a further written agreement duly signed by or on behalf of each party. (d) Nothing in this agreement shall create or be deemed to create a partnership or relationship of principal and agent between the parties. … Appendix 1 PROGRAMME OF WORK The programme proposes to create a Windows based user friendly software that uses latest information on in vitro - in vivo extrapolation to predict metabolic drug-drug interactions. There are a number of techniques (using software equations) which are used to do in vitro - in vivo extrapolation. Our software will include number of these options in a library of models which can be selected and employed by the end user. Sponsors, depending on the level of support, may ask for specific routines of extrapolation (common to their practice) to be included in the library. University will advertise and recruit a suitable computer programmer with some knowledge of modelling/simulation to produce the software. The first step in the programming will be to convert prototype of SIMCYP (written in MathCad) to Windows based program. Upon successful completion of the first stage (5-6 months) sponsors will be invited to review the programme and draft their suggestions and include additional features that they would like to incorporate into the software. These will be considered by principal investigators and efforts will be made to incorporate such additional features. However, the proportion of additional features from the list of suggested features will depend on the relative contributions received from each sponsor as well as scientific validity of such features. A second review of the software will take place at a later stage (8-10 months) and final comments on improvements/enhancements of specific aspects will be received from the sponsors. The programme will be completed by 12 months and the software at this stage will be considered as the final product. Any additional work on software from that point will depend on reaching an agreement for extension of contract between all (/part of) sponsors and the Univ of Sheffield. … Appendix 5 Sponsor Cyprotex Ltd Contribution£17,000 sterling Payment terms Six months after signature …”
“In relation to authorship, it seems to me that two matters have to be addressed. First it is necessary to determine whether the putative author has contributed the right kind of skill and labour. If he has then it is necessary to decide whether his contribution was big enough. The latter issue in particular is a matter of fact and degree.”
“But, so far as I am aware, there is no principle of English Law which provides that a contract cannot in any circumstances have retrospective effect, or that, if it purports to have, in fact, retrospective effect, it is in law a nullity. ... Often, as I say, the ultimate contract expressly so provides. I can see no reason why, if the parties so intend and agree, such a stipulation should be denied legal effect.”
“assuming that the University can finalise the agreement he can start work alongside you and Geoff [Tucker]”
“Strictly speaking I should not put any effort behind this [project] until we have that [agreement] but things have dragged on and if you are willing (and I assume you are only waiting for the paper work) I would like to press on with things as soon as Duncan [Edwards] is fully on board.”
“38. The relevant principles relating to the construction of disputed contractual terms and as to the material that is admissible to assist in that exercise are well-known, being enshrined in the frequently cited cases involving the construction of commercial contracts and of terms incorporated into them from related contracts. The following is a summary of these principles. 1. The meaning of a document (or of any other utterance) is that that would be given to it by a reasonable person having all the background knowledge which would reasonably be available to the parties in the situation in which they were at the time of the contract. That meaning is the meaning that the parties using those words against the relevant background would reasonably have been understood to have intended.1 2. If something appears to have gone wrong with the language and the natural and ordinary meaning of the words used flouts business commonsense, that meaning must yield to business commonsense.2 3. In the case of doubt, wording in a contract is to be construed against a party: (a) who seeks to rely on it in order to diminish or exclude his basic obligation; and (b) who proposed it for inclusion in the contract.3 4. When interpreting words of incorporation, a literal meaning is not usually to be given to them. Instead, the words should be adapted or interpreted so as to give effect to the context from which they have been drawn and into which they have been inserted. This process involves an intelligent and not a mechanical approach to interpretation.4 5. There is no fixed rule in any category of commercial contract that terms incorporated from one contract should bear a fixed or standard meaning in the second contract.5 6. In determining whether a particular obligation has been incorporated from the primary contract where the words of incorporation are general, only those terms inthe primary contract which are germane to the rights and obligations of the parties under the secondary contract and are not ancillary to them will be incorporated into the secondary contract. 6 1. I.C.S. Ltd. V West Bromwich B.S. [1998] 1 W.L.R. 896 (H.L.(E.)) at pages 912 and 913 (principles (1) and (2)) per Lord Hoffmann. This speech adopts and develops the passages in Lord Wilberforce’s speeches on this topic in Prenn v Simmonds [1971] 1 W.L.R. 1381 (H.L.(E.) at pages 1384 -1386 and Reardon Smith Line Ltd. v Yngvar Hansen-Tangen [1976] 1 W.L.R. 989 at page 995. 2. ibid. at page 913, principle (5). Lord Hoffmann derives this principle from the speech of Lord Diplock in Antaios Compania Naaviera S.A. v Salen Rederierna A.B. [1985] A.C. 191 (H.L.(E.))at page 201. 3. Youell and Others v Bland Welch Co Ltd and Others [1992] 2 Lloyd’s Rep. 127 (C.A.) at page 134 (right hand column) per Staughton L.J. who also pointed out that these are the two components of what is usually referred to as the contra proferentem rule in the singular. 4. The “Annefield” [1971] 1 Lloyd’s Rep. 1 (C.A.). All three judgments (Lord Denning M.R., Phillimore L.J.and Cairns L.J.) repay careful study. The principle here stated is drawn from that of Cairns L.J. at page 6 (right hand column). 5. Miramar Maritime Corporation v Holborn Oil Trading Ltd. [1984] A.C. 676 (H.L.(E.)) per Lord Diplock at page 688 in relation to the incorporation of terms of a charter party into a bill of lading. However, the principle was clearly stated to be of general application in cases of commercial contract incorporation. 6. The “Annefield”, ibid. at page 4 per Lord Denning M.R. and AIG Europe (UK) Ltd v Anonymous Greek Company of General Insurances, the “Etniki” [1999] Lloyd’s Rep IR 221 at page 227 (left hand column) per Colman .J.”
“made solely by employees of Sponsors”
“shall belong to each Sponsor respectively”
“conceived and/or made by one or more members or other agents of the University acting either on their own or jointly with one or more employees of the Sponsors”
“(7) Circumstances may exist when the necessity for an assignment of copyright may be established. As [counsel for the plaintiff] has submitted, these circumstances are, however, only likely to arise if the Client needs in addition to the right to use the copyright works the right to exclude the Contractor from using the work and the ability to use the copyright against third parties. Examples of when this situation may arise include: (a) where the purpose in commissioning the work is for the Client to multiply and sell copies in the market for which the work was created free from the sale of copies in competition with the Client by the Contractor or third parties; (b) where the Contractor creates a work which is derivative from a pre-existing work of the Client, eg when a draughtsman is engaged to turn designs of an article in sketch form by the Client into formal manufacturing drawings and the draughtsman could not use the drawings himself without infringing the underlying rights of the Client; (c) where the Contractor is engaged as part of a team with employees of the Client toproduce a composite or joint work and he is unable, or cannot have been intended to be able, to exploit for his own benefit the joint work or indeed any distinct contribution of his own created in the course of his engagement: see Nichols Advanced Vehicle Systems Inc v Rees[1979] RPC 127 at 139 and consider Bogrich v Shape Machines unreported4 November 1994 and in particular page 15 of the transcript of the judgment of Aldous J.”
“where the purpose in commissioning the work was to transform a research and development program containing a ground-breaking new technique for drug research that had been developed by the Client into a user-friendly program capable of being marketed to the pharmaceutical industry world-wide on a major scale by the Client and where the Contractor creating that marketable program would already have been granted by the commissioning agreement a licence to use the program for its own internal purposes connected with different but related areas of research but had not been granted the right to market the program without a subsequent agreement being negotiated with the Client.”