“the authors have argued that approximately one half of MTCT of HIV occurs late in pregnancy, possibly in the days before delivery, as the placenta begins to separate from the uterine wall. Only a small proportion of MTCT (<4%) seems to occur in the first trimester and less than 20% by 36 weeks of gestation” 8. In her evidence, Dr Herbert states: “There are a number of factors which can affect transmission risk to the baby. HIV is monitored by blood tests looking at the immune system as measured by a CD4 count, and the amount of virus in the blood (the HIV viral load). When people are not on treatment for a long time, or have never been on treatment, the virus level can be anywhere from 20,000 to over 1 million, and usually will increase over time without treatment as the immune system becomes weakened and is unable to manage the infection to keep the virus under control. Children can manage the infection differently to in adults. I am not a paediatrician but AMC was diagnosed aged 11 and that she has had very little treatment over the years. Notwithstanding her viral load level has remained low (9000-13200) during her time with us. She has therefore remained well but this level of virus poses a significant risk of transmission to the baby. Any viral load greater than 400 poses a risk to the baby. For that reason, ordinarily treatment is provided to get the viral load in the mother to an undetectable (or at least <400 copies/ml) level as soon as possible before delivery.”
“On13th January 2023 she presented to Norfolk and Norwich Hospital. She told the clinicians there that she had moved there, and that her husband had a new job, (he does not). She had told the clinicians in Kettering that she went to Norfolk for a wedding. She told me she cannot drive, but when asked how she travelled to Norfolk this week, she said she could drive and was back in Norwich giving a present to her partner’s cousin. (She had told the team in Norwich she had returned to go to the bank). All of the matters above give rise to a serious concern that even if though she consents now to provide her child with the necessary anti-retroviral medication, there is a significant risk that she will change her mind and not consent to or administer it after delivery. In those circumstances, and in light of the considerable risks (set out below) to the child if the medication is not given, I support the application for an order that, if the event that C does not consent, he court does so for the child to be given the necessary medication.”
“9.1.6 Timing of neonatal PEP All infant PEP should be started within 4 hours of delivery. There are no clear data on how late infant PEP can be initiated and still have an effect, but all effective studies of infant PEP have started treatment early and animal data show a clear relationship between time of initiation and effectiveness, with no benefit demonstrated if commenced after >72 hours [48-50]. Immediate administration of PEP is especially important where the woman has not received any ART.”
“It is usual that the child will have HIV antibodies showing at birth as these cross the placenta from the mother. The other tests are likely to give a more accurate indication as to whether the infection has been transmitted. But it takes time for the results to be known. In respect of the viral load blood test, results can be available within hours as they are processed on the hospital site. The samples for the pro-viral DNA have to be sent to a specialist laboratory and are not usually available for up to 2 weeks. The tests are repeated because research has shown that it is possible to have a negative HIV virus test at birth but for it to become positive at two weeks or later.”
“[22] JH has long been of the belief that his stomach pains are in some way related to his Asperger’s Syndrome. He has held this view for most of his adult life. It is misconceived. But many people hold irrational, inaccurate or even superstitious views in relation to their own health. In the context of Covid-19 vaccinations, a significant cohort of people do not accept or trust the accuracy of orthodox, peer-reviewed medical opinion and guidance. None of this is to be equated with lack of capacity. It is simply a facet of human nature.”